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目的研究HPV分型及其高危亚型与宫颈病变程度的关系。方法采用HPV基因分型技术对2014年7月至2015年8月在广州中医药大学第一附属医院妇科门诊就诊和体检的3 142例患者进行HPV分型检测,其中327例患者进行宫颈病理检查,分析高危型HPV感染与宫颈病变程度的关系。结果 3 142例受检对象中,21种HPV型别均被检测出,阳性检出者共969例,总检出率为30.80%,其中高危型741例,检出率为23.58%。随着宫颈病变级别的升高,高危型HPV阳性率也相应升高(P<0.05),HPV16型感染阳性者宫颈癌发生率最高(P<0.05)。高危型HPV阳性者中单一感染和多重感染与宫颈病变程度无关(P>0.05)。结论高危型HPV亚型检测在宫颈病变预防和诊治中具有重要意义。
Objective To study the relationship between HPV typing and its high risk subtypes and cervical lesions. Methods Three hundred and seventy-two patients with gynecological outpatient visits and physical examinations in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from July 2014 to August 2015 were tested by HPV genotyping for HPV typing. 327 of them were examined by cervical pathology , Analysis of high-risk HPV infection and the relationship between the degree of cervical lesions. Results Among the 3 142 subjects tested, 21 HPV types were detected. A total of 969 positive cases were detected with a total detection rate of 30.80%, of which 741 were high-risk cases with a detection rate of 23.58%. With the increase of cervical lesions, the positive rate of high-risk HPV was also increased (P <0.05), and the highest incidence of cervical cancer was HPV16-positive (P <0.05). High-risk HPV-positive single infection and multiple infections have no relationship with the degree of cervical lesions (P> 0.05). Conclusion The detection of high-risk HPV subtypes is of great importance in the prevention and treatment of cervical lesions.