论文部分内容阅读
目的 探讨高脂血症模型与患者血脂、血糖和凝血因子的变化及其关系。方法 用家兔制作高脂血症模型 3 0例并在临床随机抽取高脂血症患者和正常人各 40例 ,检测其血脂、血糖和凝血指标 ,将结果进行比较。结果 高脂血症家兔模型和临床病例的TC、TG、LDL -C和Glu显著升高 (均P <0 0 1) ,APTT和Fbg具有显著变化 (均P <0 0 1) ,PT和TT无改变 (均P >0 0 5 ) ;而HDL -C在模型中增高 (P <0 0 1)、临床病例没有变化 (P >0 0 5 )。结论 高脂血症模型与患者的血脂变化有所区别 ,但两者均可伴有糖代谢异常 ,同时可影响内源性凝血系统使血液呈高凝状态
Objective To investigate the changes of hyperlipidemia and the changes of blood lipids, blood glucose and blood coagulation factors in patients with hyperlipidemia. Methods 40 rabbits were randomly divided into hyperlipidemia group and control group. 40 cases of hyperlipidemia and 40 cases of normal people were randomly divided into two groups. Blood lipids, blood glucose and blood coagulation indexes were measured and the results were compared. Results The levels of TC, TG, LDL-C and Glu in rabbits and clinical cases of hyperlipidemic rabbits were significantly increased (all P <0.01), APTT and Fbg had significant changes (all P <0.01) TT did not change (all P> 0.05); while HDL-C increased in the model (P <0.01), and there was no change in the clinical cases (P> 0.05). Conclusions The hyperlipemia model is different from the blood lipid profile of patients, but both of them may be associated with abnormal glucose metabolism and may affect the endogenous coagulation system to make the blood hypercoagulable