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目的 验证国产盐酸格拉司琼注射预防恶性肿瘤患者化疗所致恶心与呕吐的有效性和安全性。方法 对 6 9例接受以顺铂为主化疗和 40例接受以蒽环类抗肿瘤药为主化疗的恶性肿瘤患者 ,采用前瞻性多中心随机对照试验 ,比较国产格拉司琼和国产上市恩丹西酮预防化疗所致恶心与呕吐的疗效和不良反应。结果 格拉司琼和恩丹西酮对预防强致吐和中度致吐化疗药物所致的急性和迟发性恶心与呕吐的疗效基本相同 ;不良反应亦基本相似 ,以便秘、疲倦及头痛为多见 ,但程度轻 ,不影响继续治疗。结论 :国产盐酸格拉司琼注射液预防肿瘤患者化疗所致的恶心与呕吐是安全和有效的。
Objective To verify the efficacy and safety of domestic granisetron hydrochloride injection in preventing chemotherapy-induced nausea and vomiting in patients with malignant tumors. Methods Sixty-nine patients receiving cisplatin-based chemotherapy and 40 patients receiving anthracycline-based anticancer chemotherapy were prospectively randomized prospective multicenter randomized controlled trials comparing domestic granisetron with domestic listed Ondan Efficacy and side effects of hydrocortisone in preventing nausea and vomiting induced by chemotherapy. Results Granisetron and ondansetron had the same efficacy in preventing acute and delayed nausea and vomiting induced by strong and moderate emetogenic chemotherapeutic drugs. Adverse reactions were also similar, with constipation, fatigue and headache as More common, but to a lesser extent, does not affect the continued treatment. Conclusion: Granisetron HCl injection is safe and effective in the prevention of chemotherapy-induced nausea and vomiting in cancer patients.