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目的:通过对比的方法,评价特比萘芬片和酮康唑片治疗霉菌性阴道炎的疗效和安全性。方法:将120例霉菌性阴道炎患者随机分成2组。实验组采用特比萘芬片治疗75例,对照组采用酮康唑片治疗75例。经过2周的治疗疗程,观察疗效。通过两独立样本t检验的统计学方法,对2组的疗效进行统计学分析。结果:在120例患者中,特比萘芬片治疗组有效率96.21%,酮康唑片治疗组的有效率为87.15%。经两独立样本t检验两两比较,特比萘芬片治疗组的有效率均高于单独用酮康唑片组,P值为0.023(小于0.05)。在2组治疗过程中,患者均未出现严重不良反应,2周后,均对2组患者的肝功能进行抽血检测,发现2组肝功能均无显著性变化,与正常肝功能比较差异无统计学意义(P<0.05)。结论:特比萘芬片治疗霉菌性阴道炎的效果明显好于单独服用酮康唑片的有效率。同时,在2种药物的治疗过程中,均无出现严重的不良反应和肝功能受损的情况。
Objective: To evaluate the efficacy and safety of terbinafine tablets and ketoconazole tablets in the treatment of mycotic vaginitis. Methods: 120 cases of fungal vaginitis were randomly divided into two groups. The experimental group treated with terbinafine 75 cases, the control group treated with ketoconazole 75 cases. After 2 weeks of treatment, observe the effect. Through two independent samples t test statistical methods, the efficacy of two groups were statistically analyzed. Results: In 120 patients, the effective rate of terbinafine tablets group was 96.21%, and that of ketoconazole tablets group was 87.15%. After two independent samples t-test comparison, the effective rate of terbinafine tablets treatment group were higher than the ketoconazole alone tablets group, P value of 0.023 (less than 0.05). In the two groups, no serious adverse reactions occurred in the patients. Two weeks later, the liver function of the two groups were tested for blood tests. There was no significant difference between the two groups in liver function, with no significant difference compared with normal liver function Statistical significance (P <0.05). Conclusion: The effect of terbinafine in the treatment of mycotic vaginitis is better than that of ketoconazole alone. At the same time, there was no serious adverse reactions and impaired liver function in the treatment of the two drugs.