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目的了解1999～2003年洋葱伯克霍尔德菌分布以及耐药状况,为临床有效治疗和预防洋葱伯克霍尔德菌感染提供依据.方法从各类标本中分离出洋葱伯克霍尔德菌株并利用API系统鉴定.采用Kir-bu-Bauer法进行药敏试验.结果共分离出513株洋葱伯克霍尔德菌.该菌普遍分布于很多科室,尤其以泌尿内科、泌尿外科和重症监护病房为多见.洋葱伯克霍尔德菌的耐药率呈逐年上升趋势,对亚胺培南、头孢他啶、头孢吡肟和阿米卡星的耐药率已从1999年的5.0%、8.4%、15.2%和31.1%,分别上升至2003年的44.9%、34.6%、40.3%和66.3%.洋葱伯克霍尔德菌对头孢哌酮/舒巴坦和哌拉西林/三唑巴坦的耐药率最低.结论洋葱伯克霍尔德菌已经成为一个重要的院内感染的致病菌并且对大多数的抗生素耐药.为了有效的治疗和预防洋葱伯克霍尔德菌感染,应进行动态细菌监测.“,”[Objective] To investigate the distribution and resistance of Burkholderia cepacia to antibiotics from 1999～2003, and give clinicians information on the effective therapy and prevention of Burkholderia cepacia infections. [Method] Strains of Burkholderia cepacia were isolated from specimens and identified by API system. KirbyBauer test was used for antibiotics susceptibility. [Results] Total 513 stains of Burkholderia cepacia were isolated.Burkholderia cepacia had been isolated in many departments and was especially common in the department of nephrology, department of urology and intensive care units (ICUs). The resistance to antibiotics is inclined to rise year by year in this study. The resistance to imipenem, ceftazidime, cefepime and amikacin rose from 5.0%, 8.4%,15.2% and 31.1% in 1999, to 44.9%, 34.6%, 40.3% and 66.3% in 2003 respectively. Burkholderia cepacia displayed the lowest resistance to cefoperazone/sulbactam and piperacillin/tozobatam. [ Conclusions] Burkholderia cepacia has become an important pathogen of nosocomial infection and is resistant to most antimicrobial agents. The continual resistance surveillance is very important for the effective therapy and prevention of Burkholderia cepacia infections.