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大鼠颈外静脉注射内毒素和血小板激活因子(PAF)均可诱发严重肺水肿,肺血管外水量,肺泡灌洗液中蛋白浓度、细胞计数和多形核粒细胞分类均显著增高。PAF受体拮抗剂SRI63—441对内毒素和PAF所致肺水肿和肺泡灌洗液细胞学变化有部分改善作用。
Injecting endotoxin and platelet activating factor (PAF) into the external jugular vein of rats can induce severe pulmonary edema, pulmonary extravascular water volume, protein concentration in alveolar lavage fluid, cell count and polymorphonuclear neutrophil classification were significantly increased. The PAF receptor antagonist SRI63-441 has partially improved the effects of endotoxin and PAF on pulmonary edema and cytology of BALF.