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目的探讨异位妊娠的影响因素,为减少异位妊娠的发生提供客观的依据。方法采用临床病例对照研究的方法,分析淮安市级医院2009年1月—2010年12月间收治住院确诊的138例异位妊娠患者的临床病历资料及同期门诊超声提示宫内早孕155例的临床病历资料。对可能影响异位妊娠的年龄、生活习惯、孕次、性生活时间、避孕方式、盆腔手术史、慢性盆腔感染史、血β-人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)、妊娠结局等变量,采用多因素非条件logistic回归法,筛查异位妊娠发生的危险因素。结果多因素非条件logistic回归法分析异位妊娠发生的相关危险因素及比值比(OR)分别为:放置宫内节育器(OR=4.83,P<0.01),口服紧急避孕药(OR=11.78,P<0.05),慢性盆腔感染史(OR=7.21,P<0.01),异位妊娠史(OR=6.01,P<0.05)。结论慢性盆腔感染史、口服紧急避孕药、放置宫内节育器、无避孕措施和不严格工具避孕为发生异位妊娠发生的危险因素。
Objective To investigate the influencing factors of ectopic pregnancy and provide an objective basis for reducing the incidence of ectopic pregnancy. Methods Clinical case-control study was used to analyze the clinical records of 138 cases of ectopic pregnancy diagnosed in hospital from January 2009 to December 2010 in Huaian city hospital and 155 cases of intrauterine pregnancy in the same period Medical records. On the possible influence of ectopic pregnancy age, lifestyle, pregnancy time, sex life, contraceptive methods, history of pelvic surgery, history of chronic pelvic infection, blood β-human chorionic gonadotropin (HCG), pregnancy outcome The multivariate non-conditional logistic regression was used to screen the risk factors of ectopic pregnancy. Results Multivariate non-conditional logistic regression analysis showed that the risk factors and odds ratios (OR) of ectopic pregnancy were: IUD (OR = 4.83, P <0.01), oral contraceptive (OR = 11.78, P <0.05), history of chronic pelvic infection (OR = 7.21, P <0.01) and history of ectopic pregnancy (OR = 6.01, P <0.05). Conclusion The history of chronic pelvic infection, oral emergency contraception, placement of IUD, non-contraceptive measures and non-strict contraceptive contraception risk factors for the occurrence of ectopic pregnancy.