Since the outbreak of COVID-19, various regions have introduced their own TCM prevention and treatment methods. However, there are two opposing views on the nature of cold and temperature. Since modern times, the thought of the unification of cold and temperature has developed rapidly, and many doctors gradually realized the importance and practicability of the unification of cold and temperature, and began to advocate the unification of cold and temperature syndrome. The prevention and treatment of COVID-19 in Jiangxi was developed by Professor Wu Bingcai, a master of Chinese medicine, based on the unified idea of cold and temperature, according to the characteristics of humid climate in Jiangxi, and in combination with the characteristics of COVID-19, the anti-toxin prescription for dispelling cold and desiccating dampness and the anti-toxin prescription for clearing heat and dehumidifying, which achieved exact and satisfactory results in clinical application.