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目的探讨血清降钙素原(procalcitonin,PCT)和超敏C反应蛋白(high sensitivity C-reactive protein,hsCRP)与非ST段抬高急性冠脉综合征(Non ST-elevation Acute Coronary Syndrome,NSTE-ACS)危险分层的相关性。方法选取2014年6月~2016年6月锡山人民医院心内科住院确诊为NSTE-ACS的患者96例,其中不稳定型心绞痛(unstable agina,UA)52例,非ST段抬高心肌梗死(Non-ST elevation myocardial infarction,NSTEMI)44例。入院后所有研究对象均采用全球急性冠状动脉事件注册(The Global Registry of Acute Coronary Events,GRACE)评分系统进行危险分层,分为低危组(n=34)、中危组(n=32)和高危组(n=30)。另选取同期住院非冠心病患者30例作为对照组。对各组进行PCT和hs-CRP水平检测,比较各组之间的差异,并对各组数据用Pearson相关分析探讨相关性。结果各组间hs-CRP水平对照组、低、中、高危各组之间差异有统计学意义(P<0.05),而PCT各组间差异无统计学意义(P均>0.05),Pearson相关分析显示hs-CRP与GRACE评分相关,且为正相关(r=0.724,P<0.01),PCT与GRACE评分相关性无统计学意义(r=0,P>0.05)。结论 hs-CRP与NSTE-ACS患者GRACE评分显著相关,且为正相关,在临床上可作为NSTE-ACS危险分层的实验室预测指标。PCT与NSTE-ACS患者GRACE评分相关性不明显,对NSTE-ACS危险分层预测依据不充分。
Objective To investigate the relationship between serum procalcitonin (PCT) and high sensitivity C-reactive protein (hsCRP) and non-ST-elevation acute coronary syndrome (NSTE- ACS) risk stratification correlation. Methods A total of 96 patients with NSTE-ACS diagnosed as NSTE-ACS were enrolled in the Xishan People’s Hospital from June 2014 to June 2016. Among them, 52 cases were unstable agina (UA), 52 cases were non-ST-elevation myocardial infarction -ST elevation myocardial infarction, NSTEMI) 44 cases. After admission, all subjects were stratified into risk stratification using the GRACE grading system. The patients were divided into low risk group (n = 34), moderate risk group (n = 32) And high risk group (n = 30). Another 30 patients with non-coronary inpatients during the same period were chosen as the control group. The levels of PCT and hs-CRP in each group were detected, and the differences among the groups were compared. Pearson correlation analysis was used to explore the correlation between each group. Results There was significant difference in hs-CRP levels among the three groups (P <0.05), but there was no significant difference among PCT groups (P> 0.05). Pearson correlation Analysis showed that hs-CRP was correlated with GRACE score, and there was a positive correlation (r = 0.724, P <0.01). There was no significant correlation between PCT and GRACE score (r = 0, P> 0.05). Conclusion The hs-CRP is significantly correlated with GRACE score of patients with NSTE-ACS, and it is positively correlated and clinically as a laboratory predictor of NSTE-ACS risk stratification. The correlation between PCT and NACE-GRACE score was not obvious, and the evidence of NSTE-ACS risk stratification was not sufficient.