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目的:观察男性生殖道解脲脲原体(Ureaplasma urealyticum,Uu)感染患者的精子形态学分析结果 ,探讨Uu感染对精子形态可能存在的影响。方法:2012年在上海市第一妇婴保健院生殖中心就诊的生育前检查者共258例,经排除影响因素后入组Uu感染的男性患者96例。统一治疗后,按Uu治疗结果分为Uu转阴组和未转阴组2组,比较2组间精子形态学分析结果。结果:Uu转阴组患者治疗前、后的精子正常形态率和精子头部畸形率差异均无统计学意义(P=0.09和P=0.08),但Uu治愈后较治疗前患者的精子尾部畸形率显著降低(P=0.02);而未转阴组治疗前、后的精子正常形态率、头部畸形率及尾部畸形率差异均无统计学意义(P=0.92,P=0.14,P=1.00)。Uu转阴组与未转阴组比较,患者治疗前或后的精子正常形态变化无统计学差异(P=0.83)。结论:总体上看,治疗Uu对精子形态学分析结果无明确意义,但Uu感染者治愈后的精子尾部畸形率显著降低,提示Uu可能会引起精子尾部畸形。
OBJECTIVE: To observe the morphological analysis of sperm in Ureaplasma urealyticum (Uu) infected male genital tract and explore the possible influence of Uu infection on sperm morphology. Methods: A total of 258 prenatal exams were performed at the Reproductive Center of the First Maternal and Child Health Hospital in Shanghai in 2012, and 96 males were enrolled in the study. After unite treatment, the results of Uu treatment were divided into Uu negative group and non-negative group two groups, the results of morphological analysis between the two groups were compared. Results: There was no significant difference in the normal sperm morphology and sperm head deformity between Uu negative control group before and after treatment (P = 0.09 and P = 0.08). However, Uu negative control group had significantly lower sperm tail abnormalities (P = 0.02). However, there was no significant difference in normal sperm morphology, head deformity rate and tail abnormality before and after treatment (P = 0.92, P = 0.14, P = 1.00 ). There was no significant difference in the normal morphology of spermatozoa between Uu negative control group and non-negative control group (P = 0.83). CONCLUSION: Generally speaking, treatment of Uu has no definite significance on the results of sperm morphological analysis. However, the rate of sperm tail deformity after Uu infection is significantly reduced, suggesting that Uu may cause tail sperm deformity.