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作者测试持续静脉滴注硝苯啶或者硝苯陡加美托洛尔对14例不稳定型心绞痛患者早期治疗的作用。经24小时准备后,逐步调整硝苯啶剂量(平均27±7μg/min)。硝苯啶治疗后冠脉血流量从150±66增加到183±74ml/min(P<0.05),而心率血压乘积、心肌氧耗量、动脉和冠状窦(去甲)肾上腺素浓度均无改变。心肌乳酸摄取量从3.4±26.1增加到31.1±26.6μmol/min(P<0.05),游离脂肪酸摄取量从7.2±22.1增加到34.5±33.7μmol/min(P<0.05)。氨基酸代谢略有改善,但无显著性。对了例患者加用美托洛
The authors tested the effect of continuous intravenous infusion of nifedipine or nifedipine plus metoprolol on early treatment in 14 patients with unstable angina. After 24 hours of preparation, the nifedipine dose was adjusted stepwise (mean, 27 ± 7 μg / min). Coronary blood flow increased from 150 ± 66 to 183 ± 74 ml / min (P <0.05) after treatment with nifedipine, while there was no change in heart rate and blood pressure product, myocardial oxygen consumption, arterial and coronary sinus (normoxic) . Myocardial lactate intake increased from 3.4 ± 26.1 to 31.1 ± 26.6μmol / min (P <0.05), and free fatty acid uptake increased from 7.2 ± 22.1 to 34.5 ± 33.7μmol / min (P <0.05). Amino acid metabolism improved slightly, but not significant. The case of patients with metoprolol