论文部分内容阅读
目的研究催乳素、促生长素对系统性红斑狼疮(SLE)患者Th1/Th2型细胞因子的影响。方法对SLE患者和正常人对照的淋巴细胞进行体外培养,并测定细胞因子。结果在自分泌情况下,SLE活动期患者白介素6(IL-6)、白介素10(IL-10)的分泌量显著增高,而干扰素γ(IFN-γ)的分泌量低于静止期和正常人,但差异无统计学意义。经促生长素和催乳素干预后,活动期SLE患者IL-6、IL-10分泌量显著高于自分泌量和正常人对照组。IFN-γ分泌量经促生长素和催乳素干预后,与自分泌量相比,活动期患者无显著升高。促生长素对SLE患者IL-6、IL-10、IFN-γ分泌量的影响与催乳素的影响差异无统计学意义。结论SLE患者不但存在Th2型细胞因子增高,而且促生长素和催乳素均能刺激Th2型细胞因子进一步增高,且刺激能力相当,并呈正相关。
Objective To investigate the effects of prolactin and somatotropin on Th1 / Th2 type cytokines in patients with systemic lupus erythematosus (SLE). Methods Lymphocytes of SLE patients and normal controls were cultured in vitro and cytokines were measured. Results In the case of autocrine, the secretion of interleukin 6 (IL-6) and interleukin 10 (IL-10) in patients with active SLE was significantly increased, while the secretion of IFN-γ was lower than that of quiescent and normal People, but the difference was not statistically significant. After the intervention of somatotropin and prolactin, the secretion of IL-6 and IL-10 in active SLE patients was significantly higher than that of autologous secretion and normal controls. IFN-γ secretion by the ghrelin and prolactin intervention, compared with the autocrine volume, active patients no significant increase. The effect of somatotropin on the secretion of IL-6, IL-10 and IFN-γ in patients with SLE was not significantly different from that of prolactin. Conclusions SLE patients not only have increased Th2 cytokines, but also stimulate the secretion of Th2 cytokines by somatostatin and prolactin, and they have similar stimulating ability and positive correlation.