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目的观察二甲双胍联合达英治疗多囊卵巢综合症的临床效果。方法选取医院多囊卵巢患者150例,平均分成二甲双胍组、达英组及综合组各50例,记录观察3组在服用药物前后相关临床症状变换与各项激素水平及2种药物联合使用的临床效果。结果二甲双胍组多毛、痤疮、月经紊乱患者治愈率分别为62.50%、52.63%、77.50%,达英组分别为61.11%、45.00%、75.00%,而综合组治愈率分别为80.00%、85.71%、88.57%,综合组治愈率高于二甲双胍组、达英组(P<0.05)。联合用药组服药后T、FINS、LH、DHEAS、FBG、TG均较治疗前、二甲双胍组治疗后、达英组治疗后显著降低,SHBG水平显著提高(P<0.05)。结论二甲双胍联合达英-35治疗多囊卵巢综合症效果相比于单纯使用达英-35,用对于改善患者临床症状和各项内分泌激素水平具有更佳的效果,值得在临床上推广应用。
Objective To observe the clinical effect of metformin combined with dynorphin in the treatment of polycystic ovary syndrome. Methods A total of 150 patients with polycystic ovary were randomly divided into metformin group, da-Ying group and 50 cases in combination group. The changes of clinical symptoms and hormone levels before and after taking the drugs and the combination of two drugs effect. Results The cure rate of metformin group was 62.50%, 52.63% and 77.50% respectively for methotrexate group and 61.11%, 45.00% and 75.00% respectively for metformin group, and 80.00% and 85.71% for combination group respectively, 88.57%. The cure rate of the combination group was higher than that of the metformin group and the Darlene group (P <0.05). After treatment with metformin, the levels of T, FINS, LH, DHEAS, FBG and TG in the combination group were significantly lower than those in the metformin group before treatment, and SHBG levels were significantly increased (P <0.05). Conclusions Metformin combined with da-Ying-35 treatment of polycystic ovary syndrome compared with the simple use of da-Ying-35, with the clinical symptoms for the improvement of patients with various levels of endocrine hormones have better results, it is worth in the clinical application.