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目的 了解鸟类耳中毒后氨基甙类药物外环境的持续存在是否影响其听功能的恢复。方法 将罗曼小鸡于生后第 3天开始按 2 0 0mg .kg-1.d-1连续肌肉注射卡那霉素 10天。然后再随机分组。经典施药组 :不再注射任何药物 ,于药毕后 1、3、7、10、15天时接受ABR检测。延长施药组 :继续按 2 0 0mg .kg-1.d-1肌肉注射卡那霉素 ,于连续给药 13、17、2 0、2 5、30天时接受ABR检测。结果 小鸡延长施药时 ,其ABR阈移于连续施药 10天时达到极限 (约 4 3dB) ;其后虽继续施药 ,鸡听功能已开始恢复。连续施药 2 0天内 ,鸡听功能的恢复与施药 10天即停药者非常相似 ;施药 2 0天后 ,鸡听功能出现下降趋势 ,至连续施药 2 5天时 ,鸡ABR阈值已显著高于施药 10天毕后 15天时 ,差异非常显著 ;连续施药 30天时 ,鸡ABR阈值明显高于连续施药 2 0天时 ,差异亦有统计学意义。结论 卡那霉素延长施与阻碍了鸡耳中毒后听功能的恢复。
Objective To understand whether persistence of aminoglycoside external environment after ear ototoxicity affects the recovery of hearing function. Methods Romans chickens were injected intramuscularly with kanamycin at the dose of 200 mg · kg-1.d-1 for 10 days after birth. Then randomly grouped. Classical administration group: No further injection of any drug, ABR testing at 1,3,7,10,15 days after the completion of the drug. To extend the application group: Continue to press kanamycin intramuscularly at 200 mg. Kg-1.d-1 for ABR at 13, 17, 20, 25 and 30 days after continuous administration. Results The results showed that the threshold of ABR threshold reached the limit (about 4 3dB) when the chickens prolonged the application of pesticides. Afterwards, the chicken hearing function started to recover. During 20 days of continuous application, the recovery of chicken hearing function was very similar to that of drug-withdrawal for 10 days. After 20 days of application, the chicken-hearing function showed a downward trend. By the time of 25 days of continuous application, the chicken ABR threshold was significant Which was significantly higher than that at the 10th day after the tenth day of application. The threshold of ABR in the chickens was significantly higher than that of the continuous application for twenty days after the continuous spraying for 30 days, the difference was also statistically significant. Conclusions The prolongation of kanamycin can hinder the recovery of hearing function after the chicken ear poisoning.