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目的:探讨非洛地平缓释片与氯沙坦联合应用对老年高血压合并2型糖尿病患者的肾脏保护作用。方法:选取老年原发性高血压合并2型糖尿病患者121例,在常规降糖基础上口服非洛地平缓释片(5mg qd)+氯沙坦片(50mg bid)治疗12周;入选健康人97例作为对照,测定对照组及联合组治疗前后的肾功能指标:血尿素氮(BUN)、血肌酐(Cr)、肾小球滤过率(e GFR)、尿微量白蛋白(m Alb)。结果:治疗前联合组的肾功指标分别与对照组、治疗后联合组进行比较,差异都明显为(P<0.05)。结论;在对患者常规降糖治疗的基础上,联合非洛地平缓释片与氯沙坦片可有效改善老年高血压并2型糖尿病患者的肾损害,减少不良事件发生。
Objective: To explore the protective effect of felodipine combined with losartan on the renal hypertension in elderly patients with type 2 diabetes mellitus. Methods: A total of 121 elderly patients with essential hypertension and type 2 diabetes mellitus were enrolled in this study. They were treated with 5 mg qd and 50 mg bid on the basis of conventional hypoglycemic therapy for 12 weeks. 97 cases were taken as the control to measure the renal function indexes of the control group and the combined group before and after treatment: BUN, Cr, e GFR, m Alb, . Results: Before treatment, the renal function indexes in the combined group were compared with those in the control group and the post-treatment combined group, respectively (all P <0.05). Conclusions. On the basis of routine hypoglycemic treatment, the combination of sustained-release tablets and losartan tablets can effectively improve the renal hypertensive patients with type 2 diabetes and reduce the incidence of adverse events.