鱼藤酮是一种线粒体复合体Ⅰ抑制剂,因其诱导帕金森病动物模型在病理学等方面优于其他现有动物模型而引起学者们的关注。一般来说,制备鱼藤酮诱导鼠科动物模型的给药方式主要有口服法、皮下注射法、腹腔注射法、微泵静脉灌注射法和黑质立体定向注射法等。模型制备结束后进行行为学评价,主要方法有摆体试验、昏厥试验、疲劳性转棒试验和阿扑吗啡诱导攀爬试验等。动物和给药两个方面因素都会影响鱼藤酮诱导鼠科动物模型的成功制备与否。 Rotenone, a mitochondrial complex I inhibitor, has drawn the attention of scholars for its animal model of Parkinson’s disease that is superior to other existing animal models in pathology and other aspects. In general, the preparation of rotenone-induced murine animal model of administration mainly oral, subcutaneous injection, intraperitoneal injection, micro-pump intravenous injection and substantia nigra stereotactic injection. Behavioral evaluation was conducted after the preparation of the model. The main methods include pendulum test, syncope test, fatigue test and apomorphine induction test. Both animal and drug administration influence the successful preparation of rotenone-induced murine models.