有关HLAII类基因的研究已经涉及到遗传学、免疫学、临床医学。其中HLAII与自身免疫性疾病的相关性是非常重要且引人注目的问题,特别是HLAII类基因与糖尿病相关性研究已取得了一定的结论,HLAII类基因与病理性妊娠的相关研究也有所进展。妊娠期糖尿病的病因及发病机理目前尚不清楚。妊娠期糖尿病为糖尿病的一独立特殊型,它与HLAII类基因相关性的研究已开始起步,不同的HLAII类基因可能控制妊娠期糖尿病的抑制性和易感性。 Studies on HLA class II genes have involved genetics, immunology, and clinical medicine. Among them, the relationship between HLAII and autoimmune diseases is very important and compelling issues, especially the relationship between HLA class II genes and diabetes has made some conclusions, the HLA class II genes and pathological pregnancy also have some progress . The etiology and pathogenesis of gestational diabetes is not yet clear. Gestational diabetes mellitus is an independent and special type of diabetes. Studies on its association with HLA class II genes have started. Different HLA class II genes may control the inhibitory and susceptibility of gestational diabetes mellitus.