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目的观察分析熊去氧胆酸(UDCA)在乙型肝炎病毒感染相关婴儿肝炎综合征(HIS)的临床效果。方法选取我院2013年6月~2015年6月收治的60例乙型肝炎病毒感染相关婴儿肝炎综合征病例,运用双色球随机分组法分为观察组(n=30)和对照组(n=30),对照组患儿给予常规治疗,观察组患儿给予熊去氧胆酸治疗,评估治疗效果。结果观察组患儿治疗总有效率86.67%,高于对照组70.00%;治疗后两组患儿肝功能指标明显改善,观察组患儿ALT低于对照组(P<0.05)。结论针对乙型肝炎病毒感染相关婴儿肝炎综合征患儿,采用熊去氧胆酸治疗,有利于减轻临床症状,提高治疗有效率,值得临床推广应用。
Objective To observe and analyze the clinical effect of ursodeoxycholic acid (UDCA) on infantile hepatitis syndrome (HIS) associated with hepatitis B virus infection. Methods Sixty cases of infantile hepatitis associated with hepatitis B infection were selected from June 2013 to June 2015 in our hospital. The patients were divided into observation group (n = 30) and control group (n = 30) ), The control group of children given conventional treatment, the observation group of children given ursodeoxycholic acid treatment, to assess the therapeutic effect. Results The total effective rate of treatment group was 86.67%, higher than that of control group 70.00%. After treatment, the liver function indexes of two groups were significantly improved. The ALT in observation group was lower than that in control group (P <0.05). Conclusion The treatment of ursodeoxycholic acid in children with hepatitis B syndrome associated with hepatitis B virus infection is beneficial to relieve the clinical symptoms and improve the treatment efficiency, which is worthy of clinical application.