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目的 观察分析视网膜母细胞瘤 (Retinoblastoma,Rb)的病理形态和临床表现。方法 对 98例 Rb眼球摘除标本进行病理切片形态观察和免疫组化染色观察。结果 98例 Rb临床与病理分期符合率 5 5 .11%。肿瘤常见坏死、钙化。瘤细胞显示 NSE阳性和 S1 0 0 、 GFAP阳性的细胞。结论 Rb的临床与病理分期有一定差异。肿瘤坏死与瘤细胞分化相关 ,钙化是肿瘤的特征表现。肿瘤含有 NSE阳性的神经元性瘤细胞和 S1 0 0 、GFAP阳性的反应性增生的胶质细胞。
Objective To observe the pathological features and clinical manifestations of Retinoblastoma (Rb). Methods 98 cases of Rb enucleated specimens were observed by pathological sections and immunohistochemical staining. Results The coincidence rate of clinical and pathological staging of 98 cases of Rb was 55.11%. Common tumor necrosis, calcification. The tumor cells showed NSE-positive and S100, GFAP-positive cells. Conclusion Rb clinical and pathological staging have some differences. Tumor necrosis is associated with tumor cell differentiation and calcification is a hallmark of tumors. The tumors contained NSE-positive neuronal tumor cells and S100, GFAP-positive, reactive hyperplastic glial cells.