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目的考察不同比例人参皂苷Re与黄连素对2型糖尿病的降血糖作用。方法采用均匀设计法对人参皂苷Re与黄连素进行不同比例配比,通过淀粉(6 mg/g)诱导小鼠高血糖模型,STZ(150μg/g)和ALX(200μg/g)法诱导大鼠2型糖尿病模型。观察人参皂苷Re与黄连素6种比例(2∶0、16∶1、1∶2、8∶4、0∶8、4∶16)(100μg/g)对血糖的影响。结果人参皂苷Re与黄连素1∶2组、8∶4组和4∶16组(100μg/g)连续给药15天可显著降低淀粉(6 mg/g)诱导正常小鼠餐后血糖的升高(P<0.05,P<0.01)。其中,人参皂苷Re与黄连素1∶2组和4∶16组(100μg/g)可显著抑制STZ所致糖尿病大鼠血糖水平(P<0.05,P<0.01);而人参皂苷Re与黄连素4∶16组(100μg/g)对ALX(200μg/g)所致糖尿病大鼠血糖的升高也具有显著抑制作用(P<0.01),其效果类似降糖灵(100μg/g)。此外,在STZ和ALX诱导大鼠高血糖模型中,人参皂苷Re与黄连素各比例之间进行比较发现,人参皂苷Re与黄连素4∶16(100μg/g)对血糖的抑制作用要优于其他组(P<0.05)。结论人参皂苷Re与黄连素4∶16(100μg/g)具有显著的降血糖作用。
Objective To investigate the hypoglycemic effects of different concentrations of ginsenoside Re and berberine on type 2 diabetes mellitus. Methods Ginseng saponins Re and berberine were mixed with different proportions by uniform design. Rats were induced by starch (6 mg / g) induced hyperglycemia model, STZ (150μg / g) and ALX (200μg / g) Type 2 diabetes model. The effects of ginsenoside Re and berberine at the ratio of 2: 1, 16: 1, 1: 2, 8:4, 0:8, 4:16 (100μg / g) on blood glucose were observed. Results The continuous administration of ginsenoside Re with berberine 1: 2, 8: 4 and 4: 16 (100μg / g) for 15 days significantly reduced the postprandial glucose uptake in normal mice induced by starch (6 mg / g) High (P <0.05, P <0.01). Among them, ginsenoside Re and berberine 1: 2 group and 4:16 group (100μg / g) significantly inhibited blood glucose levels in STZ-induced diabetic rats (P <0.05, P <0.01); while ginsenoside Re reacted with berberine 4:16 group (100μg / g) also had a significant inhibitory effect on the increase of blood glucose in ALX (200μg / g) -induced diabetic rats (P <0.01), and its effect was similar to that of hypoglycemic (100μg / g). In addition, the comparison of the ratios of ginsenoside Re and berberine in STZ and ALX-induced rat hyperglycemia models found that Ginsenoside Re and berberine 4:16 (100 μg / g) Other groups (P <0.05). Conclusion Ginsenoside Re and berberine 4:16 (100μg / g) have a significant hypoglycemic effect.