目的 :探讨激素替代治疗对人工绝经后更年期综合征的防治作用 ,及其用于早期子宫内膜癌术后低复发危险妇女的必要性和安全性。方法 :观察 5 1例人工绝经后妇女口服倍美力 (结合型雌二醇 ,E2 ) 0 .6 2 5 mg/ d,6个月后更年期综合征症状 ,血雌激素水平 ,血脂 ,骨代谢生化指标及腰椎、骨盆 X线检查的变化。结果 :激素替代治疗可有效改善更年期综合征症状 ,调节血脂成分 ,降低总胆固醇及高密度脂蛋白水平 ,并有效抑制骨吸收 ,各指标较用药前均有显著性差异 (P<0 .0 5或 P<0 .0 1) ;13例低复发危险的子宫内膜癌术后妇女用药后随访 2年未出现复发病例。结论 :人工绝经妇女应尽早进行激素替代治疗。常规剂量的激素替代治疗尚不能阻止人工绝经 <2年的妇女骨质快速脱钙。激素替代治疗对低复发危险的子宫内膜癌术后妇女是必要的 ,其安全性有待进一步观察 Objective: To investigate the effect of hormone replacement therapy on menopause syndrome after artificial menopause and its necessity and safety for women with low recurrence after early endometrial cancer. Methods: 51 patients with postmenopausal women were treated orally with estradiol (E2) 0.6525 mg / d for 6 months. The symptoms of climacteric syndrome, blood estrogen level, blood lipid, bone metabolism Biochemical indicators and lumbar, pelvis X-ray examination changes. Results: Hormone replacement therapy can effectively improve the symptoms of menopause syndrome, regulate blood lipid components, reduce total cholesterol and high density lipoprotein levels, and effectively inhibit bone resorption, the indicators were significantly different from before treatment (P <0.05 Or P <0.01). No postoperative recurrence was found in 13 cases of postoperative women with endocarcinoma who had a low risk of recurrence after 2 years of follow-up. Conclusion: Artificial menopause women should take hormone replacement therapy as soon as possible. Hormone replacement therapy at conventional doses has not stopped rapid bone decalcification in women <2 years of artificial menopause. Hormone replacement therapy is necessary for postoperative women with a low risk of recurrent endometrial cancer, and its safety remains to be seen