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目的 观察腺苷对慢性低氧高二氧化碳大鼠血流动力学的影响及氨茶碱的拮抗作用。方法 从大鼠肺动脉内注入腺苷溶液。氨茶碱组大鼠预先注入氨茶碱进行处理。结果 2 5 μg·kg-1·min-1组 (T组 ) ,5 0 μg·kg-1·min-1组 (F组) ,10 0 μg·kg-1·min-1组 (H组 )用药后平均肺动脉压(mPAP)分别降低 18 5 %± 9 9% ,2 7 1%± 4 5 % ,37 2 %± 7 2 % ,明显低于用药前 (P均 <0 0 1) ,而NO水平则明显升高 (P <0 0 5 ,P <0 0 1,P <0 0 1)。T组 ,F组用药后mPAP/mSAP(平均体循环压 )明显低于用药前 (P <0 0 1,P<0 0 5 ) ,H组差异无显著性 (P >0 0 5 )。氨茶碱组用药后mPAP与F组比较差异有显著性 (P <0 0 1)。结论 腺苷剂量依赖性降低慢性低氧高二氧化碳大鼠的肺动脉高压 ,其机制可能部分依赖于内皮细胞NO的释放。小剂量腺苷对肺循环具有良好选择性。氨茶碱能拮抗腺苷舒张肺血管的作用。
Objective To observe the effect of adenosine on the hemodynamics of chronic hypoxic hypercapnic rats and the antagonism of aminophylline. Methods Adenosine solution was infused into rat pulmonary artery. Aminophylline rats were pretreated with aminophylline. Results Twenty-five μg · kg-1 · min-1 group (group T), 50 μg · kg-1 · min-1 group (group F) and 100 μg · kg-1 · min-1 group ) After treatment, mean pulmonary arterial pressure (mPAP) decreased by 18.5% ± 9 9%, 271% ± 45%, 37 2% ± 72% respectively, which was significantly lower than that before treatment (P <0.01) While NO levels increased significantly (P <0.05, P <0.01, P <0.01). The mean mPAP / mSAP (mean systemic pressure) in group T and group F after medication was significantly lower than that before treatment (P <0.01, P <0 05). There was no significant difference between group H and group H (P> 0.05). The aminophylline group mPAP compared with the F group after the difference was significant (P <0 01). Conclusions Adenosine reduces pulmonary hypertension in chronic hypoxia-hypercapnia rats in a dose-dependent manner, which may partly depend on the release of NO from endothelial cells. Small doses of adenosine on the pulmonary circulation has good selectivity. Aminophylline can antagonize the role of adenosine relaxation of pulmonary vessels.