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目的:评价精神疾病与乳腺癌发病率的关系。方法:检索CNKI、Pubmed、EMBASE、OVID、SIENCEDIRECT、万方数据库,获取关于精神疾病与乳腺癌发病率的队列研究,按照纳入、排除标准选择文献,并从纳入排除标准中提取相关数据,以乳腺癌的SIR(标化患病率)为效应值,应用Stata12.0以固定效应模型对研究的原始数据进行Meta分析。结果:最终纳入9个研究。Meta分析结果显示:精神分裂症或者乳腺癌SIR合并值为1.19,95%CI(1.12,1.26)。情感障碍患者乳腺癌SIR合并值为1.04,95%CI(1.00,1.09)。结论:精神疾病与乳腺癌存在相关性,并可能是乳腺癌患病危险因素。
Objective: To evaluate the relationship between mental illness and the incidence of breast cancer. Methods: The CNKI, Pubmed, EMBASE, OVID, SIENCEDIRECT and Wanfang databases were searched to obtain a cohort study on the incidence of mental illness and breast cancer. According to the inclusion and exclusion criteria, the relevant data were extracted and the relevant data were extracted from the exclusion criteria. The SIR (normalized prevalence) of cancer was the effect value and Meta analysis of the raw data was performed using the fixed effect model using Stata12.0. Results: Nine studies were eventually included. Meta-analysis showed that schizophrenia or breast cancer SIR combined value was 1.19,95% CI (1.12,1.26). Emotional disorders breast cancer SIR combined value of 1.04, 95% CI (1.00,1.09). Conclusion: Mental illness is associated with breast cancer and may be a risk factor for breast cancer.