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评估代谢综合征(MS)高危因素人群胰岛β细胞生理作用情况(分泌,抵抗),为早期预防提供参考依据。2014年3月~2015年3月收集我院体检人群数据,入选240例MS高危男性受试者。通过口服葡萄糖耐量试验和胰岛素刺激试验,空腹及糖负荷后1/2 h和2 h两个时间的的血糖、胰岛素及C肽水平将被观察检测,从而评估胰岛β细胞功能及胰岛素抵抗情况。OGTT结果表明血糖正常组、糖尿病前期组和伴糖尿病组MS患者分别为148例(61.7%)、76例(31.7%)、16例(6.6%)。各组血糖、胰岛素和C肽的体内变化曲线发现各组的指标随着时间慢慢升高后缓慢下降,最后趋于平缓。餐后1/2 h和2 h时间点,发现血糖异常的两组胰岛素及C肽仅I_(2h)、C_(1/2h)及C_(2h)与正常组相比具有一定差异,且C_(1/2h)与正常组相比有下降趋势,I_(2h)、C_(2h)与正常组相比则有所提高。伴糖尿病的MS患者胰岛素抵抗指标HOMA-IR、IAI、ISIc显著高于正常血糖的MS患者。与正常血糖MS患者相比,糖尿病前期MS患者和伴糖尿病MS患者的HBCI、IGI都显著降低。综上所述,MS人群虽然FBG早期未出现紊乱现象,当给予糖负荷后,其血糖发生异常变化,该危险不容忽视。MS患者具有潜在的糖尿病风险,因此,通过探讨MS高危人群的胰岛分泌功能及胰岛素抵抗情况,对早期预防有一定指导价值。
To assess the physiological role of pancreatic islet β cells in patients with metabolic syndrome (MS) risk factors (secretion, resistance), provide a reference for early prevention. From March 2014 to March 2015, we collected the data of medical examination in our hospital and selected 240 MS high-risk male subjects. Through oral glucose tolerance test and insulin stimulation test, blood glucose, insulin and C-peptide levels will be observed at 1/2 h and 2 h after fasting and glucose load to evaluate islet β cell function and insulin resistance. OGTT results showed that 148 patients (61.7%), 76 patients (31.7%) and 16 patients (6.6%) were MS patients with normal blood glucose, pre-diabetes and diabetes mellitus. The in vivo changes of blood glucose, insulin and C-peptide in each group showed that the indexes of each group decreased slowly with the increase of time and finally tended to be gentle. At 1 hour and 2 hours postprandial, there were some differences between the two groups of insulin and C-peptide (I_ (2h), C_ (1 / 2h) and C_ (2h) (1 / 2h) decreased compared with the normal group, I_ (2h), C_ (2h) increased compared with the normal group. MS patients with diabetes mellitus insulin resistance indicators HOMA-IR, IAI, ISIc was significantly higher than normal blood glucose in patients with MS. HBCI and IGI were significantly lower in patients with pre-diabetic MS and those with diabetes mellitus than those with normal glucose MS. To sum up, although there is no disorder in the early stage of FBG in MS population, abnormal changes of blood glucose after given glucose load can not be neglected. MS patients have a potential risk of diabetes, therefore, by exploring the MS at-risk populations of pancreatic islet secretion and insulin resistance, the prevention of some guidance value.