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多囊卵巢综合征(PCOS)与2型糖尿病(T2D)都是与肥胖密切相关的健康问题,有着相似的流行病学特征和病理生理因素。其中,肥胖带来的胰岛素抵抗是两者发病的一个共同的关键因素。然而,胰岛素抵抗影响PCOS和T2D发病的机制却有着显著的不同——在PCOS中,代偿性的高胰岛素血症产生多重生物效应,其中包括影响卵巢和肾上腺的促性腺作用;而在T2D,胰岛素抵抗可促使β细胞衰竭,最终导致胰岛素缺乏而造成糖代谢紊乱。PCOS与1型糖尿病(T1D)的关联被认为主要是在体内循环系统中胰岛素水平和生物效应的改变上。肥胖的继续流行注定肥胖相关的一系列疾病将变得更加普遍,其中就包括PCOS和2型糖尿病。为此,我们首先需要进一步弄清楚各疾病的病理生理机制。
Polycystic ovary syndrome (PCOS) and type 2 diabetes (T2D) are closely related to obesity health problems, have similar epidemiological characteristics and pathophysiological factors. Among them, insulin resistance caused by obesity is a common key factor in the pathogenesis of both. However, there is a striking difference in the mechanisms by which insulin resistance affects the pathogenesis of PCOS and T2D - compensatory hyperinsulinemia has multiple biological effects in PCOS, including gonadal effects on ovaries and adrenal glands, and in T2D, Insulin resistance can promote β-cell failure, eventually leading to insulin deficiency caused by glucose metabolism disorders. The association of PCOS with type 1 diabetes mellitus (T1D) is thought to be mainly in the changes of insulin levels and biological effects in the circulatory system of the body. The continued popularity of obesity A number of diseases associated with obesity will become more prevalent, including PCOS and type 2 diabetes. To this end, we first need to further clarify the pathophysiology of each disease.