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恶性症侯群是由抗精神病药引起的黑质纹状体和脊髓多巴胺(DA)受体过度抑制所致的锥体外和植物神经等全身重笃症候群,其诊断和严重程度判断在血清学检查结果的意义尚未解决之前,只能根据临床症状、血清CPK、LDH值等来判断。本文报道的3例皆在患病期间由于应用抗精神病药引起,年龄偏大,从55岁至62岁,发病后急送转综合医院,先后经支持疗法和肌肉松弛药与催乳激素抑制剂,病情皆痊愈。在恶性症候群的重笃时期,经检查尿中肾上腺素(AD)、去甲肾上腺素(NA)均示异常高值,特别NA的上升更明显。然而,随着临床症状的改善,尿中AD、NA浓度下降。相反,DA浓度在整个病程中处正常范围。因此认为,恶性症候群从全身性NA过剩状态来
Malignant disease group is caused by antipsychotic nigrostriatal and spinal cord dopamine (DA) receptor over-inhibition caused by extrapyramidal and autonomic nervous system and other important symptoms, the diagnosis and severity of judgment in serological tests The significance of the results have not been resolved before, only based on clinical symptoms, serum CPK, LDH value to judge. In this paper, all three cases are caused by the application of antipsychotics during the illness, older age, from 55 years to 62 years old, after the onset of emergency transfer to General Hospital, successively through the supportive therapy and muscle relaxants and prolactin inhibitors, the disease All recovered. During the period of severe death in malignant syndrome, abnormal urinary adrenaline (AD) and norepinephrine (NA) showed abnormally high values, especially NA. However, with the improvement of clinical symptoms, urinary AD, NA concentrations decreased. In contrast, DA concentration is normal in the course of the disease. Therefore, it is considered that the malignant syndrome comes from the state of excess of systemic NA