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目的：评价应用体外受精－胚胎移植（ＩＶＦ－ＥＴ）治疗８５例不孕患者的临床结果。方法：用药方案有：①ＧｎＲＨａ／ＦＳＨ／ｈＭＧ；②ＧｎＲＨａ／ＦＳＨ；③ＧｎＲＨａ／ｈＭＧ。培养液包括Ｅａｒｌｅ’ｓ平衡盐液及人类输卵管液（ＨＴＦ）。结果：８５例进行了１０９个ＩＶＦ周期治疗，１２个周期（１１０％）因反应不良而取消。每周期获取卵母细胞（１０２±５４）个，卵子受精率６８９％，卵裂率６０８％，每个转移胚胎植入率７７％（３１／４０２）。９４个移植周期中，每周期移植（４９±２４）个胚胎，获２０次临床妊娠（２１３％）。采用ＨＴＦ妊娠率为２２４％，高于应用Ｅａｒｌｅ’ｓ液的妊娠率（１８５％），但差异无统计学意义。２０次妊娠患者中，１次输卵管妊娠，４次自然流产（２０％），５例足月分娩，１０例继续妊娠。多胎妊娠率４０％，重度ＯＨＳＳ发生率４１％。结论：ＩＶＦ－ＥＴ是治疗输卵管因素、子宫内膜异位症等不孕症的重要而有效的手段。体外培养时用ＨＴＦ可能优于Ｅａｒｌｅ’ｓ液，而有利于提高妊娠率。
OBJECTIVE: To evaluate the clinical outcomes of 85 infertile patients treated with IVF-ET. Methods: Medication programs are: ① GnRHa / FSH / hMG; ② GnRHa / FSH; ③ GnRHa / hMG. The medium includes Earle’s Balanced Saline and Human Fallopian Tube Fluid (HTF). Results: Eighty-five patients underwent 109 cycles of IVF and 12 cycles (11.0%) were discontinued due to poor response. Obtain oocytes (102 ± 54) per cycle. The fertilization rate was 689%, cleavage rate was 608%, and implantation rate was 77% (31/402) per transfer embryo. Of the 94 transplant cycles, 4 (9 ± 24) embryos were transplanted per week and 20 clinical pregnancies (213%) were obtained. The pregnancy rate with HTF was 224%, which was higher than that with Earle’s fluid (185%), but the difference was not statistically significant. Among 20 pregnancies, one had tubal pregnancy, four spontaneous abortions (20%), five full-term deliveries, and 10 continued pregnancy. Multiple pregnancy rate of 40%, severe OHSS incidence of 4 1%. Conclusion: IVF-ET is an important and effective treatment for infertility such as tubal factors and endometriosis. In vitro culture with HTF may be better than Earle’s solution, which will help to improve the pregnancy rate.