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目的:观察早期布鲁菌病（简称布病）患者血清软骨寡居基质蛋白（COMP）及Ⅱ型胶原羧基端肽（CTX-Ⅱ）水平变化，探讨布病早期阶段骨关节生物标志物的改变状况。方法:采用病例对照研究方法，选取2013 - 2016年在青海省地方病预防控制所布病预防控制科就诊的早期布病患者，设为病例组；通过随机匹配原则，将健康体检人群设为对照组。使用酶联免疫吸附法检测两组人群血清COMP、CTX-Ⅱ水平并进行分析。结果:共调查128人，其中61名（41名男性和20名女性）早期布病患者，年龄为（39.41 ± 10.51）岁；67名健康对照（44名男性和23名女性），年龄为（40.31 ± 12.52）岁。病例组血清COMP中位数为1.70 μg/L，显著高于对照组（0.79 μg/L），二者比较差异有统计学意义（n Z = 3.614，n P 0.05）。n 结论:早期布病患者血清COMP含量增加，提示在布病早期存在骨关节相关改变。“,”Objective:To detect cartilage oligomeric matrix protein (COMP) and C-terminal telopeptide of collagen type Ⅱ (CTX-Ⅱ) among brucellosis patients at early period, and provide a better understanding of the osteoarticular changes in this disease at early stage.Methods:Using case-control research method, the early brucellosis patients who visited the Department for Brucellosis Disease Prevention and Control, Qinghai Institute for Endemic Disease Prevention and Control from 2013 to 2016 were selected as the case group; through the principle of random matching, the healthy physical examination population was set as the control group. Serum COMP and CTX-Ⅱ were detected by enzyme-linked immunosorbent assay.Results:A total of 128 patients were investigated, including 61 patients (41 males and 20 females) with early brucellosis, aged (39.41 ± 10.51) years old, and 67 controls (44 males and 23 females), aged (40.31 ± 12.52) years old. The median of serum COMP in the case group was 1.70 μg/L, which was significantly higher than that in the control group (0.79 μg/L). The difference between the two groups was statistically significant ( n Z = 3.614, n P 0.05).n Conclusion:The serum COMP levels of brucellosis patients at early period are increased, indicating osteoarticular changes of human brucellosis at early stage.