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目的:探讨典型视网膜色素变性晚期自发荧光影像与中心视力关系。方法:晚期典型视网膜色素变性37例( 70眼),采用HRA-2共焦激光扫描系统获取眼底自发荧光影像,视野30°,像素1 536×1 536,瞳孔直径>6mm,部分患者进行FERG和Humphrey静态视野检查。结果:根据自发荧光影像表现将所有患者分为4种类型,即完整型、斑驳型、孤岛型和中心低荧光型。不同类型的自发荧光表现出不同的中心视力。结果证实,眼底自发荧光影像改变与中心视力高度相关,自发荧光面积与视力有显著差异(n=57,r=0.385,P<0.01),自发荧光面积与年龄有显著差异(n=57,r=-2.67,P<0.05)。结论:自发荧光影像对于中心视力的监测和预测具有实际价值。自发荧光变化与中心视力相关,不同的荧光类型视力改变程度不同。尽管视网膜色素变性仍无彻底治愈方法,但保护性治疗是必要的,如抑制细胞凋亡、改善供血以及营养神经元等。
Objective: To investigate the relationship between autofluorescence and central visual acuity in patients with typical retinitis pigmentosa. Methods: Forty-seven cases (70 eyes) with typical retinal pigment degeneration were included in this study. HRF-2 confocal laser scanning system was used to acquire autofluorescence images of the fundus. The visual field was 30 °, with a pixel of 1 536 × 1 536 and pupil diameter of 6 mm. Humphrey Static Field Examination. Results: According to autofluorescence imaging, all patients were divided into 4 types: complete type, mottled type, island type and central low fluorescence type. Different types of autofluorescence show different central vision. The results confirmed that the change of fundus autofluorescence was highly correlated with central vision. There was significant difference between autofluorescent area and visual acuity (n = 57, r = 0.385, P <0.01). There was significant difference between autofluorescence area and age = -2.67, P <0.05). CONCLUSIONS: Autofluorescence imaging is of practical value in the monitoring and prediction of central vision. Autofluorescence changes associated with central vision, different types of fluorescence changes in visual acuity. Although there is still no complete cure for retinitis pigmentosa, protective treatments are necessary, such as inhibiting apoptosis, improving blood supply, and nourishing neurons.