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目的：旨在探讨持续性第一肝门阻断是否有细菌移位发生及其可能的相关机制。方法：采用第一肝门阻断后不同时相组织中１３１Ｉ标记大肠杆菌的检测；肠组织血流量测定；门、腔静脉内毒素，门脉ＰＯ２测定；肠组织形态学分析。结果：第一肝门阻断１５ｍｉｎ即有细菌移位发生，各组织中标记大肠杆菌的每分钟脉冲数随着肠组织损伤程度的加剧，肠组织血流量，门脉ＰＯ２的下降，门、腔静脉内毒素水平的升高而进行性上升。结论：第一肝门阻断１５ｍｉｎ即有细菌移位发生。推测细菌移位是肠组织血流量、门脉ＰＯ２下降，内毒素血症致肠屏障功能受损协同作用的结果。
Objective: To investigate whether there is bacterial translocation in persistent first hepatic hilus and its possible related mechanism. Methods: The detection of 131I-labeled Escherichia coli in different time-phase tissues after the first hepatic portal vein occlusion was performed; the blood flow of intestinal tissue was measured; the portal venous toxin and portal vein PO2 were measured; RESULTS: Bacterial translocation occurred after the first hepatic portal vein was blocked for 15 minutes. The number of pulses per minute labeled with E. coli in each tissue increased with the severity of intestinal tissue damage, the intestinal blood flow, the decrease of portal PO2, Increased intravenous toxins and increased sexually. Conclusion: The first hepatic portal block 15min that bacterial translocation occurs. It is speculated that bacterial translocation is a result of the synergistic effect of intestinal tissue blood flow, decreased portal PO2, and impaired intestinal barrier function caused by endotoxemia.