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目的探讨亚临床甲状腺功能减退症(SCH)与急性冠脉综合征患者血脂、脑钠肽(BNP)、空腹血糖(FBG)、血肌酐(Scr)、血清同型半胱氨酸(Hcy)的关系。方法选取ACS患者468例,根据甲状腺功能是否正常分为甲状腺功能正常组(EUT组)426例和SCH组42例。按照住院病历资料记录患者的年龄、吸烟史、身高、体质量和血压,计算体质量指数。检测FBG、BNP、Hcy、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、促甲状腺素(TSH)、甲状腺激素和Scr。结果 SCH组患者的年龄、Scr、FBG、BNP和TSH水平明显高于EUT组,差异均有统计学意义(P<0.05或0.01)。结论 SCH可影响ACS患者的BNP、Scr、FBG及TSH等代谢,重视纠正甲状腺功能有利于改善ACS患者的预后。
Objective To investigate the relationship between subclinical hypothyroidism (SCH) and serum lipid, brain natriuretic peptide (BNP), fasting blood glucose (FBG), serum creatinine (Scr) and serum homocysteine (Hcy) in patients with acute coronary syndrome . Methods 468 ACS patients were selected and divided into 426 cases of normal thyroid function group (EUT group) and 42 cases of SCH group according to whether the thyroid function was normal. The body mass index was calculated according to the age, smoking history, height, body weight and blood pressure of inpatient records. The levels of FBG, BNP, Hcy, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), thyrotropin (TSH), thyroid Hormones and Scr. Results The age, Scr, FBG, BNP and TSH levels in SCH group were significantly higher than those in EUT group, with statistical significance (P <0.05 or 0.01). Conclusions SCH can affect the metabolism of BNP, Scr, FBG and TSH in patients with ACS. Emphasis on correcting thyroid function can improve the prognosis of patients with ACS.