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特发性血小板增多症(ET)和其他骨髓增生性疾病(MPD)一样,是一种多能造血干细胞肿瘤克隆性疾病。研究表明,所有骨髓增生性综合征粒-单系和红系祖细胞在体外有异常集落形成。集落数目常增多。许多病人在没有促红细胞生成素刺激的条件下,能自发性形成红系集落。但对有关巨核祖细胞的变化了解得很少。采用血浆凝块法对一些病人进行研究,所得结果不一。本文采用甲基纤维素法研究了12例ET 患者血和骨髓巨核祖细胞集落形成,并以22例骨髓移植供者作为对照。
Idiopathic thrombocythemia (ET), like other myeloproliferative disorders (MPD), is a clonogenic disease of pluripotent hematopoietic stem cells. Studies have shown that all myelodysplastic syndrome granulocyte-monocyte and erythroid progenitor cells have aberrant colony formation in vitro. The number of colonies often increases. Many patients spontaneously develop erythroid colonies without erythropoietin stimulation. But little is known about the changes in megakaryocyte progenitors. The use of plasma clot method for some patients to study, the results obtained vary. In this paper, 12 cases of ET patients with blood and bone marrow megakaryocyte progenitor colony formation was studied by methylcellulose method, and 22 cases of bone marrow transplantation donor as a control.