2012年5月本实验室对北京16家实验动物单位的啮齿类实验动物的心、肝、脾、肺、肾、大肠和小肠进行组织病理学观察,通过石蜡切片HE染色、冰冻切片油红O染色、PAS染色等方法对啮齿类实验动物的健康状况进行鉴定。结果显示,绝大多数啮齿类实验动物为健康状态,部分非健康动物主要有肝脏脂肪变性、轻度肺脏病变、心脏颗粒变性和肾脏蛋白管型。这可能与饲养环境、饲料状况以及采样运输的应激有关,通过加强饲养管理可以使这种情况改善。 In May 2012, we observed the histopathological changes of heart, liver, spleen, lung, kidney, large intestine and small intestine of 16 experimental animal units in Beijing. The cells were stained by paraffin section HE, Staining, PAS staining and other methods to identify the health status of rodents experimental animals. The results showed that the vast majority of rodents experimental animals are healthy, some non-healthy animals mainly have liver steatosis, mild lung disease, cardiac granular degeneration and renal tubular protein. This may be related to the feeding environment, the status of the feed and the stress of the sample transport, which can be improved by better feeding and management.