异种器官移植是可望缓解可供移植的人类脏器日益短缺矛盾的有效途径，超急性排斥反应（ＨＡＲ）是阻止其成功的关键［１］。为研究其发生机制和有效抑制手段，我们建立了将豚鼠肾脏移植至大白鼠颈部的异种、异位肾移植ＨＡＲ模型，现报告如下。１　材料和方法１．１　材料　豚 Xenotransplantation is an effective way to alleviate the contradiction between the growing number of human organs available for transplantation. Hyperacute rejection (HAR) is the key to preventing its success [1]. In order to study its mechanism of occurrence and effective inhibition, we have established HAR model of xenotransplantation of guinea pig kidney transplanted to the neck of rats, are as follows. 1 materials and methods 1.1 material dolphin