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目的探讨比索洛尔对慢性心力衰竭的临床治疗效果。方法 102例慢性心力衰竭患者作为此次研究对象,随机分为治疗组和对照组,各51例。对照组给予低剂量(日用量≤5.00 mg)比索洛尔治疗,治疗组给予高剂量(日用量≥7.50 mg)比索洛尔治疗,比较两组患者临床效果。结果治疗前两组患者的心率、收缩压、舒张压、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)水平、B型利钠肽(BNP)、舒张早期和晚期最大血流速度比(E/A)水平对比差异无统计学意义(P>0.05);治疗后两组患者的心率、收缩压、舒张压、LVEF、LVEDD、BNP以及E/A水平均显著改善(P<0.05),且治疗组显著优于对照组(P<0.05)。治疗组患者治疗总有效率为96.1%,明显高于对照组的80.4%,差异具有统计学意义(χ2=6.044,P=0.014<0.05)。治疗组患者不良反应发生率为9.8%,与对照组的3.9%对比,差异无统计学意义(χ2=1.380,P=0.240>0.05)。结论比索洛尔治疗慢性心力衰竭患者能够获得较好的临床效果,能够显著提高患者心功能与心肌重构,只要患者能够耐受则应尽量让比索洛尔达到目标剂量治疗,高剂量作用更为显著。
Objective To investigate the clinical effect of bisoprolol on chronic heart failure. Methods A total of 102 patients with chronic heart failure were randomly divided into treatment group and control group, with 51 cases in each. The control group was treated with bisoprolol in low dose (≤5.00 mg daily). The treatment group was treated with bisoprolol in high dose (≥7.50 mg daily), and the clinical effects were compared between the two groups. Results Before treatment, heart rate, systolic blood pressure, diastolic blood pressure, left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), B-type natriuretic peptide (BNP), early diastolic and late maximum blood flow Heart rate, systolic blood pressure, diastolic blood pressure, LVEF, LVEDD, BNP and E / A in both groups were significantly improved after treatment (P < 0.05), and the treatment group was significantly better than the control group (P <0.05). The total effective rate of the treatment group was 96.1%, which was significantly higher than that of the control group (80.4%), the difference was statistically significant (χ2 = 6.044, P = 0.014 <0.05). The incidence of adverse reactions in the treatment group was 9.8%, which was not significantly different from that in the control group (χ2 = 1.380, P = 0.240> 0.05). Conclusion Bisoprolol in patients with chronic heart failure can achieve better clinical results, can significantly improve the patient’s cardiac function and myocardial remodeling, as long as the patient can tolerate the bisoprolol should be as high as possible to achieve the target dose of treatment Significant.