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目的:探讨局部晚期鼻咽癌(LA-NPC)患者IMRT同步化疗后影响预后因素。方法:收集2010—2019年间解放军总医院第六医学中心肿瘤科收治的136例LA-NPC患者临床资料，所纳入患者均采用同步放化疗，分析各因素对LA-NPC患者总生存(OS)和无进展生存(PFS)的影响。n Log-n rank检验进行单因素预后分析，n Cox回归进行多因素预后分析。使用“rms”R包绘制列线图。n 结果:中位随访时间为56个月(10～98个月)。全组患者1、3、5年OS率分别为97.1%、85.9%、70.2%, 1、3、5年PFS率分别为84.5%、64.5%、50.2%。多因素分析显示LDH浓度≥178 U/L、颅底受侵、顺铂累积剂量<200mg/mn 2、Nn 3期、EGFR表达阳性患者OS越短(均n P<0.05); LDH浓度≥178U/L、颅底受侵、顺铂累积剂量<200mg/mn 2的患者PFS越短(均n P<0.05)。将多因素分析有预后意义的变量构建预后模型，模型对1、3、5年OS预测效能分别为0.91、0.9、0.8，对1、3、5年PFS预测效能分别为0.82、0.78、0.78。n 结论:LDH、颅底受侵、顺铂累积剂量、N分期、EGFR阳性可能作为评估LA-NPC患者预后指标。“,”Objective:The paper aims to investigate factors that affect the prognosis in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) after concurrent IMRT and chemotherapy.Methods:Clinical data from 136 patients with LA-NPC were collected at the Department of Oncology, the Sixth Medical Center of PLA General Hospital from 2010 to 2019. All patients were treated with concurrent radio-chemotherapy. Then, we analyzed the effects of potential factors on overall survival (OS) and progression-free survival (PFS) for patients with LA-NPC. Log-rank test was performed for univariate analysis. Cox regression analysis was performed for multivariate analysis. Two nomograms were plotted by using rms package in R.Results:The median follow-up time was 56 months (10-96 months). The 1-, 3- and 5-year OS rate were 97.1%, 85.9% and 70.2%, respectively. The 1-, 3-, and 5-year PFS rate were 84.5%, 64.5% and 50.2%, respectively. Multivariate analysis showed that those participants with shorter OS had LDH concentration ≥178U/L, skull destroyed, cisplatin cumulative dose < 200mg/m n 2, Nn 3 stage and positive EGFR expression (n P<0.05). Participants with shorter PFS had LDH concentration≥178U/L, skull destroyed, cisplatin cumulative dose < 200mg/mn 2 (n P<0.05). According to the results, a prognostic model was constructed for predicting the OS. The predictive efficiency for 1-, 3-, and 5-year OS were 0.91, 0.9 and 0.8, respectively. A prognostic model was constructed for predicting the PFS. The predictive efficiency for 1-, 3-, and 5-year PFS were 0.82, 0.78 and 0.78, respectively.n Conclusions:Our results suggest that LDH, skull destroyed, cisplatin cumulative dose, N stage and positive EGFR expression might be used as prognostic factors associated with poor OS or PFS in patients with LA-NPC.