糖尿病会损害众多器官,其中对肾最显著。一半以上的Ⅱ型糖尿病患者和1/3的Ⅰ型糖尿病人会发生肾功能异常。糖尿病肾病是糖尿病常见的并发症之一,也是导致慢性肾功能衰竭的主要原因,其早期肾脏损害主要表现为高血糖引起的肾小球组织结构和滤过功能破坏,并导致蛋白尿。该病发病机制复杂,无形之中给临床治疗带来了巨大挑战,用LXR激动剂抑制糖尿病 Diabetes can damage many organs, most notably the kidneys. More than half of type 2 diabetic patients and 1/3 of type 1 diabetes patients will have renal dysfunction. Diabetic nephropathy is one of the common complications of diabetes mellitus, which is also the main cause of chronic renal failure. Its early renal damage mainly manifests as glomerular tissue structure and filtration dysfunction caused by hyperglycemia and leads to proteinuria. The pathogenesis of the disease is complex and invisible, which poses a great challenge to clinical treatment. LXR agonists inhibit diabetes