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痢疾菌苗的研究已有40余年历史。最近,对细菌性痢疾分子生物学认识的增进,以及有可能设计充分确定特性的菌苗株,增进了人们对这一领域的研究兴趣。对几种有希望的菌苗候选株正在进行不同水平的研究,但迄今尚无适用于公共卫生目的的志贺菌苗。本文讨论了几种不同的研制安全、有效的痢疾菌苗的方法和策略。
The study of dysentery vaccine has been more than 40 years old. Recent advances in understanding the molecular biology of bacterial dysentery and the possibility of designing vaccine strains with well-defined characteristics have led to increased interest in this area of research. Several promising strains of vaccine candidates are being studied at different levels, but so far no Shigella vaccines are available for public health purposes. This article discusses several different approaches and strategies to develop safe and effective dysentery vaccines.