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目的探讨血清腺苷脱氨酶(ADA)在水痘病诊断中的临床价值。方法应用酶显色法检测105例水痘患者血清ADA活性,同时检测对照组80例丘疹性荨麻疹患者血清ADA活性,并进行比较和统计学分析。结果水痘组及对照组ADA值分别为42.39±12.26IU/L和19.88±7.25IU/L,两者ADA活性比较,差异有统计学意义(P<0.01)。在本研究的185例样本中,以ADA活性升高诊断水痘的灵敏度为0.93(99/105),特异度为0.98(79/80),Youden指数为0.93,Kappa值为0.92。结论水痘患者血清ADA活性升高,对诊断和鉴别诊断可能有一定的临床价值。
Objective To investigate the clinical value of serum adenosine deaminase (ADA) in the diagnosis of chicken pox. Methods Serum ADA activity of 105 cases of chickenpox was detected by enzymatic chromogenic method. Serum ADA activity was measured in 80 cases of papular urticaria in the control group and compared and statistically analyzed. Results The ADA values of chickenpox group and control group were 42.39 ± 12.26 IU / L and 19.88 ± 7.25 IU / L, respectively. There was significant difference in ADA activity between the two groups (P <0.01). In 185 samples of this study, the sensitivity of chicken pox with elevated ADA was 0.93 (99/105), the specificity was 0.98 (79/80), the Youden index was 0.93, and the Kappa value was 0.92. Conclusion Serum ADA activity in patients with chickenpox is elevated, which may have some clinical value for diagnosis and differential diagnosis.