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目的:评估应用糖皮质激素治疗特发性血小板减少性紫癜(ITP)发生感染的危险因素。方法:回顾了我院收治的98例患者经糖皮质激素治疗的临床资料,对是否伴有糖尿病及患者年龄进行相对危险度分析;对用药疗程及感染的发生和严重程度进行相关性分析。结果:98例经糖皮质激素治疗的患者,有21例发生感染,其中2例患者因重症感染死亡。合并糖尿病ITP患者发生感染的相对危险度为14.709(95%CI,4.788-46.984,x2=25.107,P=0.000),老年ITP患者发生感染的相对危险度为4.754(95%CI,1.321-17.102,x2=5.85,P=0.017)。用药疗程与感染的发生及严重程度的相关性均具有统计学意义(r=0.505,P=0.000及r=0.515,P=0.000)。结论:ITP患者合并糖尿病和老年患者是应用糖皮质激素发生感染的危险因素。用药疗程与感染的发生及严重程度均密切相关。
PURPOSE: To assess the risk factors for the infection of idiopathic thrombocytopenic purpura (ITP) with glucocorticoids. Methods: The clinical data of 98 patients treated with glucocorticoid in our hospital were retrospectively analyzed. The relative risk of diabetes mellitus and the age of the patients were analyzed. The incidence and severity of medication and infection were analyzed. RESULTS: In 98 patients treated with glucocorticoids, 21 were infected, and 2 of them died of severe infection. The relative risk of infection in patients with ITP was 14.709 (95% CI, 4.788-46.984, x2 = 25.107, P = 0.000). The relative risk of infection in older ITP patients was 4.754 (95% CI, 1.321-17.102, x2 = 5.85, P = 0.017). The correlation between medication course and incidence and severity of infection were statistically significant (r = 0.505, P = 0.000 and r = 0.515, P = 0.000). Conclusion: ITP patients with diabetes mellitus and elderly patients are risk factors for glucocorticoid infection. Medication and infection are closely related to the occurrence and severity.