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血脑屏障(blood brain barrier,BBB)是哺乳动物中枢神经系统中血液和脑组织之间的一种结构,由毛细血管的内皮细胞与胶质细胞紧密连接组成的细胞层组成。其功能是将血液与脑组织相对分开,是存在于脑和脊髓内的一个动态的调节界面,从而维持大脑、脊髓稳定的内环境。在机体正常情况下,BBB严格地控制血液进入脑细胞外液的物质,对中枢神经系统起到了一个重要的屏障作用。当中枢神经系统发生疾病时,在临床治疗中,很多药物,尤其是蛋白质药物不
The blood-brain barrier (BBB) is a structure between blood and brain tissue in the central nervous system of mammals. It consists of a cell layer composed of capillary endothelial cells and glial cells tightly connected. Its function is to separate the blood from the brain tissue, and it is a dynamic regulatory interface existing in the brain and spinal cord to maintain a stable internal environment of the brain and spinal cord. Under normal circumstances, BBB strictly controls the blood into the brain extracellular fluid substances, the central nervous system has played an important barrier. When the central nervous system diseases, in clinical treatment, many drugs, especially protein drugs are not