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目的:研究血管内皮生长因子(Vascularendothelialgrowthfactor,VEGF)在口腔鳞状细胞癌中的表达及其临床意义。方法:免疫组化EnVisionTM法检测VEGF在57例手术治疗的原发性OSCC(口腔鳞状细胞癌)中的表达。结果:①VEGF在OSCC中的阳性表达率为40.35%。②VEGF在不同发病部位组的表达:牙龈癌>舌癌>颊癌>唇癌,组间无统计学差异(P>0.05)。③VEGF在不同病理分级组、不同预后组、不同年龄组、不同性别组的表达无显著性差异(P>0.05);淋巴结转移组的表达显著高于无转移组(P<0.05)。结论:虽然VEGF的高表达可能在淋巴结转移中起一定的作用,但还不能作为预测口腔鳞状细胞癌临床生物学行为及预后的可靠指标。
Objective: To study the expression of vascular endothelial growth factor (Vascular endothelial growth factor) in oral squamous cell carcinoma and its clinical significance. Methods: EnVisionTM immunohistochemistry was used to detect the expression of VEGF in 57 patients with primary OSCC (oral squamous cell carcinoma). Results: ① The positive rate of VEGF in OSCC was 40.35%. ② The expression of VEGF in different sites: gingival cancer> tongue cancer> cheek cancer> lip cancer. There was no significant difference between the two groups (P> 0.05). ③ The expression of VEGF in different pathological grade groups, different prognosis groups, different age groups and different gender groups had no significant difference (P> 0.05). The expression of VEGF in lymph node metastasis group was significantly higher than that in non-metastasis group (P <0.05). Conclusion: Although the high expression of VEGF may play a role in lymph node metastasis, it can not be used as a reliable indicator to predict the clinical biological behavior and prognosis of oral squamous cell carcinoma.