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本文报告了1988年9月～1991年4月,对12例胶质瘤病人测定瘤内氨甲喋呤(MTX)含量,并经颈动脉穿刺注入罂粟碱开放血脑屏障及卡氮芥(BCNU)治疗恶性胶质瘤31例的临床研究。在12例胶质瘤病人中,经颈动脉注入罂粟碱可逆性开放血脑屏障后注入MTX,瘤内MTX含量增高,为1854±51ng/g瘤;颈动脉单纯注入MTX后为1020±51.28ng/g瘤;静脉注入MTX后瘤内含量为174±31.5ng/g瘤。31例中胶质母细胞21例,间变性星形细胞瘤10例,平均治疗2.1次,每次注入卡氮芥250mg。平均生存期101.6±32.7周,中位生存期104周。作者认为本疗法简便、安全、有效、并发症少,能延长病人生存期。
This article reports from September 1988 to April 1991, the determination of tumor methotrexate (MTX) content in 12 patients with glioma, and the injection of papaverine to open the blood-brain barrier and BCNU in the treatment of malignant Clinical Study of Gliomas in 31 Cases. In 12 patients with glioma, injection of papaverine into the blood-brain barrier reversible after carotid artery injection of MTX increased the tumor MTX content was 1854 ± 51ng / g tumor; carotid artery injection of MTX was 1020 ± 51.28ng / g tumor; intratumoral injection of MTX tumor content of 174 ± 31.5ng / g tumor. Among the 31 cases, there were 21 cases of glioblastoma and 10 cases of anaplastic astrocytoma, with an average treatment of 2.1 times. Each time they were injected with 250 mg of carmustine. The mean survival time was 101.6 ± 32.7 weeks, and the median survival time was 104 weeks. The authors believe that the therapy is simple, safe, effective, less complications, can extend the patient’s survival.