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目的:探讨严重脓毒症患者血浆肾上腺髓质素(AM)/内皮素-1(ET-1)值与并发低白蛋白血症的关系。方法:选择严重脓毒症患者38例,并以20例健康体检者作为正常对照组。采用放射免疫法测定2组血浆AM和ET-1水平。均数比较采用t检验,双变量资料采用直线相关分析。结果:①严重脓毒症组血浆AM、ET-1水平均增高,AM/ET-1值减低,与健康对照组比较有统计学意义(P<0.05);②严重脓毒症患者血清白蛋白(ALB)水平降低,与健康对照组比较有统计学意义(P<0.05);且ALB水平与AM/ET-1值呈显著正相关(P<0.05)。结论:严重脓毒症患者并发低白蛋白血症与AM/ET-1值的降低相关。
Objective: To investigate the relationship between plasma adrenomedullin (AM) / endothelin-1 (ET-1) levels and hypoalbuminemia in patients with severe sepsis. Methods: Thirty eight patients with severe sepsis were selected and 20 healthy subjects were selected as normal control group. Radioimmunoassay was used to determine plasma AM and ET-1 levels in two groups. The mean was compared using t test, bivariate data using linear correlation analysis. Results: ① The levels of plasma AM and ET-1 in patients with severe sepsis were significantly higher than those in healthy controls (P <0.05); ② Serum albumin (P <0.05). The level of ALB was positively correlated with AM / ET-1 (P <0.05). Conclusions: Hypoproteinemia is associated with decreased AM / ET-1 levels in patients with severe sepsis.