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为探讨绝经后妇女骨质疏松症与骨代谢有关酶活性变化的关系，测定了１２只７月龄新西兰兔双侧卵巢摘除前与摘除后８个月的血清碱性磷酸酶、酸性磷酸酶和骨特异性碱性磷酸酶的活性。结果：术前这３种酶的活性分别为２０．０６±８．２０、１９．０６±５．４６和１４．０４±１．６７Ｕ／Ｌ；术后８个月，分别为１４．６０±４．６４、１１．０４±４．１０和４．４４±２．１０Ｕ／Ｌ，均非常显著地低于术前（Ｐ＜０．００１）。骨特异性碱性磷酸酶的下降幅度比碱性磷酸酶大，说明以它作为骨代谢指标比碱性磷酸酶更灵敏。骨特异性碱性磷酸酶术后下降幅度也大于酸性磷酸酶。提示：这些酶的活性变化可能是绝经后妇女骨质疏松症的部分生化基础。
In order to explore the relationship between osteoporosis and bone metabolism-related enzyme activities in postmenopausal women, the changes of serum alkaline phosphatase, acid phosphatase and nitric oxide synthase were measured before and after ovariectomy in 12 rabbits of 7 months old New Zealand rabbits Bone-specific alkaline phosphatase activity. Results: The preoperative activity of these three enzymes were 20.06 ± 8.20, 19.06 ± 5.46 and 14.04 ± 1.67U / L, respectively. At 8 months after operation, the activities of these three enzymes were 14.60 ± 4.64, 11.04 ± 4.10 and 4.44 ± 2.10 U / L, all of which were significantly lower than preoperatively (P <0.001). Bone-specific alkaline phosphatase decreased more than alkaline phosphatase, indicating that it as a marker of bone metabolism more sensitive than alkaline phosphatase. Bone-specific alkaline phosphatase decreased more than acid phosphatase. Tip: Changes in the activity of these enzymes may be part of the biochemical basis of osteoporosis in postmenopausal women.