脑胶质瘤是一种死亡率较高的病变,用目前的常规治疗方法很难治愈,而硼中子俘获治疗(BNCT)是一种很有希望治愈胶质瘤的方法,但由于血脑屏障(BBB)的存在,阻止了很多含硼药物进入脑内,因此如何向瘤组织中转运足够剂量的10B,是BNCT成功应用的关键。借助肿瘤比正常组织代谢快的特点,利用针对肿瘤细胞表面特异性抗原的抗体,采取脂溶性较好的微粒包裹药物,通过电通透作用,药物破坏或者选择性开放BBB,直接颅内或者瘤内注射等方法单独或联合运用转运含硼药物,可以在瘤组织中获得理想的10B剂量,为BNCT在胶质瘤治疗中发挥重要作用奠定基础。 Glioma is a high-risk disease that is refractory to current conventional therapies. Boron neutron capture (BNCT) is a promising method of treating gliomas, but as the blood brain The presence of a barrier (BBB) ​​prevents many B-containing drugs from entering the brain, so how to deliver a sufficient dose of 10B into the tumor tissue is the key to successful BNCT application. With the rapid metabolism of tumor than normal tissue characteristics, the use of antibodies against tumor cell surface antigen-specific, fat-soluble particles to take better drug-coated, through the role of electrical penetration, drug destruction or selective open BBB, direct intracranial or tumor Injection or other methods, alone or in combination with the use of transport of boron-containing drugs, can obtain the ideal 10B dose in the tumor tissue, and lay a foundation for the important role of BNCT in the treatment of glioma.