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真核细胞降解细胞内物质主要通过2条途径——蛋白酶体降解和自噬(autophagy)降解〔1〕。蛋白酶体主要降解细胞内短寿命蛋白质;细胞内几乎全部的长寿蛋白质、多数大分子物质以及所有的细胞器都通过自噬作用被运输到溶酶体内降解,以实现细胞本身的代谢需要和细胞器的更新。因此,
Eukaryotic cells to degrade the material within the cell mainly through two ways - proteasomal degradation and autophagy (autophagy) degradation [1]. Proteasomes mainly degrade short-lived intracellular proteins; almost all of the long-lived proteins, most macromolecular substances and all organelles in the cells are transported by autophagy to lysosomes for degradation in order to achieve their own metabolic needs and organelle renewal . therefore,