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我们曾报道过经颈动脉注入罂粟碱可逆性开放血脑屏障后注入化学药物治疗大脑恶性胶质瘤。随访到1996年12月底,在1991年12月以前治疗的74例病人中有17例(23%)生存期超过5年,其中1例已存活8年3个月,表明这一方法有利于大脑恶性胶质瘤的治疗。为了找到罂粟碱开放血脑屏障的客观证据,我们于1996年10月对6只大白鼠进行了罂粟碱可逆性开放血脑屏障及脑组织的电镜观察。现将结果报告如下。
We have reported that injection of papaverine through the carotid artery reversibly opens the blood-brain barrier and injects chemotherapy to treat malignant gliomas in the brain. During the follow-up period until the end of December 1996, 17 (23%) of the 74 patients treated before December 1991 had a survival period of more than 5 years, and 1 of them had survived for 8 years and 3 months, indicating that this method is beneficial to the brain. Treatment of malignant gliomas. In order to find objective evidence for the openness of the blood-brain barrier to papaverine, we conducted a reversible open blood-brain barrier of papaverine and electron microscopy of brain tissue in 6 rats in October 1996. The results reported below.