[目的]观察荆花胃康胶丸联合埃索美拉唑治疗消化性溃疡(PU)的疗效。[方法]采用开放、随机、对照试验,将经胃镜检查确诊的97例PU患者随机分为2组,治疗组50例,口服荆花胃康胶丸160 mg/次,3次/d,埃索美拉唑40 mg,1次/d;对照组47例,口服埃索美拉唑40 mg,1次/d。治疗期间每周随访1次,记录症状转归情况。疗程结束后,胃镜复查评估溃疡愈合情况。[结果]各项临床症状的改善和疼痛消失情况2组相比差异无统计学意义(P>0.05)。PU的愈合率和总有效率治疗组分别为88.00%和98.00%,对照组为57.45%和93.62%,2组比较差异有统计学意义(P<0.05)。2组在用药期间,不良反应少,均有良好的耐受性。[结论]荆花胃康胶丸联合埃索美拉唑治疗PU可提高溃疡的愈合率和总有效率,缩短溃疡的愈合时间。 [Objective] To observe the curative effect of Jinghua Weikang capsule combined with esomeprazole on peptic ulcer (PU). [Method] The 97 patients with PU diagnosed by gastroscopy were randomly divided into two groups. The treatment group (50 cases) received Jinghua Weikang Capsule 160 mg / time, 3 times / d, Somelazole 40 mg once a day; control group, 47 patients, oral esomeprazole 40 mg once a day. Weekly treatment during treatment 1 times, record the outcome of the situation. End of treatment, gastroscopy to assess ulcer healing. [Results] There was no significant difference between the two groups in the improvement of clinical symptoms and the disappearance of pain (P> 0.05). The healing rate and total effective rate of PU in the treatment group were 88.00% and 98.00% respectively, while those in the control group were 57.45% and 93.62%. There was significant difference between the two groups (P <0.05). 2 groups in the medication period, fewer adverse reactions, have good tolerance. [Conclusion] Jinghuaweikang injection combined with esomeprazole can improve the healing rate and total effective rate of ulcer and shorten the healing time of ulcer.