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目的:观察参附注射液联合前列地尔治疗气虚血瘀型后循环缺血性眩晕的疗效。方法:将85例后循环缺血性眩晕患者随机分为2组。治疗组45例给予参附注射液40mL和前列地尔注射液20μg静脉滴注;对照组40例给予口服西比灵5mg,每天1次,2组均以14天为1疗程。监测2组患者血液流变学和后循环血流动力学指标。结果:总有效率治疗组86.7%,对照组62.5%,治疗组优于对照组(P<0.01);治疗组患者全血高、低切黏度、血浆黏度、红细胞比积、血小板聚集率的改善均优于对照组(P<0.05);治疗组后循环收缩期血流最大流速(V)s、舒张期血流最大流速(Vd)改善优于对照组(P<0.05)。结论:参附注射液联合前列地尔治疗气虚血瘀型后循环缺血性眩晕安全有效。
Objective: To observe the curative effect of Shenfu injection and alprostadil in treatment of ischemic vertigo after Qi-deficiency and blood-stasis syndrome. Methods: Eighty-five patients with posterior circulation ischemic vertigo were randomly divided into two groups. The treatment group, 45 cases given Shenfu injection 40ml and alprostadil 20μg intravenous infusion; 40 cases in the control group given oral sibirine 5mg, day 1, two groups were 14 days for a course of treatment. Hemorheology and posterior circulation hemodynamic parameters were monitored in two groups. Results: The total effective rate was 86.7% in the treatment group and 62.5% in the control group, and the treatment group was better than the control group (P <0.01). The improvement of whole blood high and low shear viscosity, plasma viscosity, hematocrit and platelet aggregation rate (P <0.05). The maximum flow velocity (V) s and the maximum diastolic flow velocity (Vd) of systolic circulation in the treatment group were better than those in the control group (P <0.05). Conclusion: Shenfu injection and alprostadil are safe and effective in treating ischemic vertigo after Qi deficiency and blood stasis syndrome.